Volume 6, Issue 6, November 2018, Page: 138-149
The Interplay Between Solar Radiation, Climate Change and Immunotoxicants in Relation to Immune Response Modulation: A Concern for Outdoor Workers’ Health
Carlo Grandi, Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers’ Compensation Authority (INAIL), Monte Porzio Catone, Italy
Maria Concetta D’Ovidio, Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers’ Compensation Authority (INAIL), Monte Porzio Catone, Italy
Received: Oct. 30, 2018;       Accepted: Nov. 21, 2018;       Published: Jan. 3, 2019
DOI: 10.11648/j.ajhr.20180606.13      View  657      Downloads  78
Immune response may be dysregulated at multiple levels for multiple reasons, spanning from congenital defects to diseases, medical treatments, environmental and occupational exposures. The consequences of immune dysregulation, especially in the case of mild immune dysfunction, are not easy to predict, being dependent on several factors, but may be subtle in most cases. Adverse health outcomes like an increased susceptibility to infections, a higher risk of cancer or the development of autoimmune diseases may occur. Outdoor workers are exposed to several risk factors, partly depending on the working activity or the job performed and partly due to the features and variability of the outdoor environment itself. Outdoor environment generally implies the exposure to severe thermal conditions, meteorological agents, environmental pollutants and solar radiation. Some volatile organic compounds, heavy metals and many pesticide display immunotoxic properties. Solar radiation itself, through the UV component, may induce immunosuppressive effects, both locally and systemically. The ongoing climate change may have a profound impact on the levels of exposure to air pollutants, pesticides, solar radiation, biological agents and disease vectors. A detailed evaluation of the combined exposure to the above-mentioned risk factors is very difficult, given the number of factors involved, the spatial and temporal variability of exposure and the high number of jobs potentially conducted outdoor, but may contribute to the definition of the “exposome” for outdoor workers. The net effect on the immune response modulation and the occurrence of the related potential adverse health outcomes are hard to predict, but this topic is of great importance for a full implementation of occupational health and safety regulation in the case of outdoor workers. This implies an integrated approach in risk assessment, a detailed evaluation of the health status during health surveillance (with particular reference to the immune function) and a careful choice of a suitable combination of preventive and protective measures at individual level.
Solar Radiation, Climate Change, Immune Toxicity, Outdoor Workers
To cite this article
Carlo Grandi, Maria Concetta D’Ovidio, The Interplay Between Solar Radiation, Climate Change and Immunotoxicants in Relation to Immune Response Modulation: A Concern for Outdoor Workers’ Health, American Journal of Health Research. Vol. 6, No. 6, 2018, pp. 138-149. doi: 10.11648/j.ajhr.20180606.13
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Bell, J. E., Brown, C. L., Conlon, K., Herring, S., Kunkel, K. E., Lawrimore, J., Luber, G., Schreck, C., Smith, A., Uejio, C. (2018). Changes in extreme events and the potential impacts on human health. Journal of Air Waste Management Association, 68,265-287. doi: 10.1080/10962247.2017.1401017.
Perkison, W. B., Kearney, G. D., Saberi, P., Guidotti, T., McCarthy, R., Cook-Shimanek, M., Pensa, M. A., Nabeel, I.; ACOEM task force on climate change. (2018). Responsibilities of the occupational and environmental medicine provider in the treatment and prevention of climate change-related health problems. Journal of Occupational and Environmental Medicine, 60, e76-e81. doi: 10.1097/JOM.0000000000001251.
D’Ovidio, M. C., Grandi, C., Marchetti, E., Polichetti, A., Iavicoli, S. (2016). Preface. Climate change and occupational health. Annali dell’Istituto Superiore Sanità, 52,323-324. doi: 10.4415/ANN_16_03_03.
Li, B., Selmi, C,. Tang, R., Gershwin, M. E., Ma, X. (2018). The microbiome and autoimmunity: a paradigm from the gut–liver axis. Cellular and Molecular Immunology 15,595-609. doi: 10.1038/cmi.2018.7.
Kerry, R. G., Patra, J. K., Gouda, S., Park, Y., Shin, H-S., Das G. (2018). Benefaction of probiotics for human health: a review. Journal of Food and Drug Analysis, 26, 927-939. doi: 10.1016/j.jfda.2018.01.002.
Sharma, A., Gilbert, J. A. (2018). Microbial exposure and human health. Current Opinion in Microbiology, 44, 79-87. doi: 10.1016/j.mib.2018.08.003.
Asif, N., Iqbal R., Nazir C. F. (2017). Human immune system during sleep. American Journal of Clinical and Experimental Immunology, 6,92-96.
Zhuang, X., 1 Rambhatla, S. B., Lai, A. G., McKeating, J. A. (2017). Interplay between circadian clock and viral infection. Journal of Molecular Medicine, 95, 1283-1289. doi: 10.1007/s00109-017-1592-7.
Colosio, C., Birindelli, S., Corsini, E., Galli, C. L., Maroni, M. (2005). Low level exposure to chemicals and immune system. Toxicology and Applied Pharmacology, 207, S320-S328.
Duramad, P., Holland, N. T. (2011). Biomarkers of immunotoxicity for environmental and public health research. International Journal of Environmental Research and Public Health, 8, 1388-1401. doi: 10.3390/ijerph8051388.
Kreitinger, J. M., Beamer, C. A., Shepherd, D. M. (2016). Environmental immunology: Lessons learned from exposure to a select panel of immunotoxicants. Journal of Immunology, 196,3217-3225. doi: 10.4049/jimmunol.1502149.
Corsini, E., Sokooti, M., Galli, C. L., Moretto, A., Colosio C. (2013). Pesticide induced immunotoxicity in humans: A comprehensive review of the existing evidence. Toxicology, 307,123-135. doi: 10.1016/j.tox.2012.10.009.
Ngobili, T. A., Daniele, M. A. (2016). Nanoparticles and direct immunosuppression. Experimental Biology and Medicine, 241, 1064-1073. doi: 10.1177/1535370216650053.
Attreed, S. E., Navas-Acien, A., Heaney, C. D. (2017). Arsenic and immune response to infection during pregnancy and early life. Current Environmental Health Reports, 4,229-243. doi: 10.1007/s40572-017-0141-4.
Fenga, C., Gangemi, S., Di Salvatore, V., Falzone, L., Libra, M. (2017). Immunological effects of occupational exposure to lead (Review). Molecular Medicine Reports, 15,3355-3360. doi: 10.3892/mmr.2017.6381.
Maqbool, F., Niaz, K., Hassan, F. I., Khan, F., Abdollahi, M. (2017). Immunotoxicity of mercury: pathological and toxicological effects. Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis Ecotoxicology Reviews, 5,29-46. doi: 10.1080/10590501.2016.1278299.
Meldrum, K., Gant, T. W., Macchiarulo, S., Leonard, M. O. (2016). Bronchial epithelial innate and adaptive immunity signals are induced by polycyclic aromatic hydrocarbons. Toxicological Research, 5,816-827. doi: 10.1039/c5tx00389j.
Abdel-Shafy, H. I., Mansour, M. S. M. (2016). A review on polycyclic aromatic hydrocarbons: source, environmental impact, effect on human health and remediation. Egyptian Journal of Petroleum, 25,107-123.
Li, Z., Tighe, R. M., Feng, F., Ledford, J. C., Hollingsworth, J. W. (2013). Genes of innate immunity and the biological response to inhaled ozone. Journal of Biochemical and Molecular Toxicology, 27, 3-16. doi: 10.1002/jbt.21453.
Veraldi, A., Costantini, A.S., Bolejack, V., Miligi, L., Vineis, P., van Loveren, H. (2006). Immunotoxic effects of chemicals: a matrix for occupational and environmental epidemiological studies. American Journal of Industrial Medicine, 49,1046-1055.
Chighizola, C., Meroni, P. L. The role of environmental estrogens and autoimmunity. (2012). Autoimmunity Reviews, 11, A493-A501. doi:10.1016/j.autrev.2011.11.027.
Chen, L., Liu, J., Zhang, Y., Zhang, G., Kang, Y., Chen, A., Feng, X., Shao, L. (2018). The toxicity of silica nanoparticles to the immune system. Nanomedicine 13, 1939-1962. doi: 10.2217/nnm-2018-0076.
Smith, M. J., Brown, J. M., Zamboni, W. C., Walker, N. J. (2014). From immunotoxicity to nanotherapy: the effects of nanomaterials on the immune system. Toxicolology Sciences, 138,249-255. doi: 10.1093/toxsci/kfu005.
Pallardy, M. J., Turbica, I., Biola-Vidamment, A. (2017). Why the immune system should be concerned by nanomaterials? Frontiers in Immunology, 8,544. doi: 10.3389/fimmu.2017.00544.
Boverhof, D. R., Ladics, G., Luebke, B., Botham, J., Corsini, E., Evans, E., Germolec, D., Holsapple, M., Loveless, S. E., Lu, H., van der Laan, J. W., White, K. L. Jr., Yang, Y. (2014). Approaches and considerations for the assessment of immunotoxicity for environmental chemicals: a workshop summary. Regulatory Toxicology and Pharmacology, 68,96-107. doi: 10.1016/j.yrtph.2013.11.012.
DeWitt, J. C., Germolec, D. R., Luebke, R. W., Johnson, VJ. (2017). associating changes in the immune system with clinical diseases for interpretation in risk assessment. Current Protocols in Toxicology, 67,18.1.1-18.1.22.
Svobodova, A., Vostalova, J. (2010). Solar radiation induced skin damage: review of protective and preventive options. International Journal of Radiation Biology, 86, 999-1030. doi: 10.3109/09553002.2010.501842.
International Agency for Research on Cancer (IARC). A review of human carcinogens. IARC monographs on the evaluation of carcinogenic risks to humans. Vol. 100 D-radiation. Lyon: IARC; 2012.
Sowa, P., Rutkowska-Talipska, J., Rutkowski, K., Kosztyła-Hojna, B., Rutkowski, R. (2013). Optical radiation in modern medicine. Postepy Dermatology and Allergology, 4,246-51. doi: 10.5114/pdia.2013.37035.
Zastrow, L., Lademann, J. (2016). Light - instead of UV protection: new requirements for skin cancer prevention. Anticancer Research, 36,1389-1394.
Grandi, C., Militello, A., Borra, M. (2018). The role of near infrared with regard to potential long-term adverse effects in outdoor workers exposed to solar radiation. Occupational and Environmental Medicine, 75, A419-A4200. 10.1136/oemed-2018-ICOHabstracts.1198
Grandi, C., Borra, M., Militello, A., Polichetti, A. (2016). Impact of climate change on occupational exposure to solar radiation. Annali dell’Istituto Superiore Sanità, 52, 3,343-356. doi: 10.4415/ANN_16_03_06.
Prasad, R., Katiyar, S. K. (2017). Crosstalk among UV-induced inflammatory mediators, DNA damage and epigenetic regulators facilitates suppression of the immune system. Photochemistry and Photobiology, 93,930-936. doi: 10.1111/php.12687.
COLIPA. (2006). International Sun Protection Factor (SPF). Test Method. Brussels, COLIPA.
Matthews, Y. J., Halliday, G. M., Phan, T. A. (2010). A UVB wavelength dependency for local suppression of recall immunity in humans demonstrates a peak at 300 nm. Journal of Investigative Dermatology, 130,1680-1684. doi: 10.1038/jid.2010.27.
Elmets, C. A., Calla, C., Xu, H. (2014). Photoimmunology. Dermatologic Clinics, 32,277-290.
Norval, M., Halliday, G. M. (2011). The consequences of UV induced immunosuppression for human health. Photochemistry and Photobiology, 87,965-977. doi: 10.1111/j.1751-1097.2011.00969.x.
Guo, B., Naish, S., Hu, W., Tong, S. (2015). The potential impact of climate change and ultraviolet radiation on vaccine preventable infectious diseases and immunization service delivery system. Expert Review of Vaccines, 14,561-567. doi: 10.1586/14760584.2014.990387.
Godar, DE. UV doses worldwide. (2005). Photochemistry and Photobiology, 81,736-749.
Milon, A., Sottas, P. E., Bulliard, J. L., Vernez, D. (2007). Effective exposure to solar UV in building workers: influence of local and individual factors. Journal of Exposure Science and Environmental Epidemiology, 17,58-68.
Modenese, A., Bisegna, F., Borra, M, Grandi, C., Gugliermetti, F., Militello, A., Gobba, F. (2016). Outdoor work and solar radiation exposure: evaluation method for epidemiological studies. Medycyna Pracy, 67,577-587.
Borra, M., Bisegna, F., Burattini C., Gobba F., Grandi C., Gugliermetti, F., Militello, A., Modenese, A. (2018). A simple method to determine the cumulative dose in outdoor workers exposed to solar radiation. Occupational and Environmental Medicine, 75, A1-A650.
Intergovernmental Panel on Climate Change (IPCC). Climate Change 2014. Synthesis Report. Geneva: IPCC; 2014.
Chiabai, A., Quiroga, S., Martinez-Juarez, P., Higgins, S., Taylor, T. (2018). The nexus between climate change, ecosystem services and human health: Towards a conceptual framework. Science of the Total Environment, 635,1191-1204. doi: 10.1016/j.scitotenv.2018.03.323.
McGushin, A., Tcholakov, Y., Hajat S. (2018). Climate change and human health: Health impacts of warming of 1.5°C and 2°C. International Journal of Environmental Research and Public Health, 15, E1123. doi: 10.3390/ijerph15061123.
Patz, J. A., Thomson, M. C. (2018). Climate change and health: Moving from theory to practice. PLoS Medicine, 15, e1002628. doi: 10.1371/journal.pmed.1002628.
Zinsstag, J., Crump, L., Schelling, E., Hattendorf, J., Maidane, Y. O., Ali, K. O., Muhummed, A., Umer, A. A., Aliyi, F., Nooh, F., Abdikadir, M. I., Ali, S. M., Hartinger, S., Mäusezahl, D., de White, M. B. G., Cordon-Rosales, C., Castillo, D. A., McCracken, J., Abakar, F., Cercamondi, C., Emmenegger, S., Maier, E., Karanja, S., Bolon, I., de Castañeda, R. R., Bonfoh, B., Tschopp, R., Probst-Hensch, N., Cissé G. (2018). Climate change and one health. FEMS Microbiology Letters, 365, doi: 10.1093/femsle/fny085.
Schulte, P. A., Chun, H. K. (2009). Climate change and occupational safety and health: establishing a preliminary framework. Journal of Occupational and Environmental Health, 6,542-554. doi:10.1080/15459620903066008
Schulte, P. A., Bhattacharya, A., Butler, C. R., Chun, H. K., Jacklitsch, B., Jacobs, T., Kiefer, M., Lincoln, J., Pendergrass, S., Shire, J., Watson, J., Wagner, G. R. (2016). Advancing the framework for considering the effects of climate change on worker safety and health. Journal of Occupational and Environmental Hygiene, 13,847-865. doi: 10.1080/15459624.2016.1179388.
Bais, A. F,. McKenzie, R. L., Bernhard, G., Aucamp, P. J., Ilyas, M., Madronich, S., Tourpali, K. (2015). Ozone depletion and climate change: impacts on UV radiation. Photochemistry and Photobiology Sciences, 14, 19-52. doi: 10.1039/c4pp90032d.
Lucas, R. M., Norval, M., Neale, R. E., Young, A. R., de Gruijl, F. R., Takizawa, Y., van Der Leun, JC. (2015). The consequences for human health of stratospheric ozone depletion in association with other environmental factors. Photochemistry and Photobiology Sciences, 14, 53-87. doi: 10.1039/c4pp90033b.
Madronich, S., Shao, M., Wilson, S. R., Solomon, K. R., Longstreth, J. D., Tang, X. Y. (2015). Changes in air quality and tropospheric composition due to depletion of stratospheric ozone and interactions with changing climate: implications for human and environmental health. Photochemistry and Photobiology Sciences, 14,149-169. doi: 10.1039/c4pp90037e.
Applebaum, K. M., Graham, J., Gray, G. M., LaPuma, P., McCormick, S. A., Northcross A., Perry M. J. (2016) An overview of occupational risks from climate change. Current Environmental Health Reports, 3, 13-22. doi: 10.1007/s40572-016-0081-4.
D’Ovidio, M. C., Annesi-Maesano, I., D'Amato, G., Cecchi, L. (2016). Climate change and occupational allergies: an overview on biological pollution, exposure and prevention. Annali dell’Istituto Superiore Sanità, 52,406-414. doi: 10.4415/ANN_16_03_12.
Gatto, M. P., Cabella, R., Gherardi, M. (2016). Climate change: the potential impact on occupational exposure to pesticides. Annali dell’Istituto Superiore Sanità, 52,374-385. doi: 10.4415/ANN_16_03_09.
Vonesch, N., D’Ovidio, M. C., Melis, P., Remoli, M. E., Ciufolini, M. G., Tomao, P. (2016). Climate change, vector-borne diseases and working population. Annali dell’Istituto Superiore Sanità, 52,397-405. doi: 10.4415/ANN_16_03_11.
Grandi, C., D’Ovidio, M. C. Occupational exposure to immunotoxicants and solar radiation in the framework of the ongoing climate change: another step in exposome profiling. 32nd ICOH Congress 2018 The Convention Centre Dublin Sun 29th April - Fri 4th May 2018. 136. A54 Occupational and Environmental Medicine 2018; 75(Suppl 2): A1-A650. 10.1136/oemed-2018-ICOHabstracts.154
Menzel, A., Matiu, M., Michaelis, R., Jochner, S. (2017). Indoor birch pollen concentrations differ with ventilation scheme, room location, and meteorological factors. Indoor Air, 27,539-550. doi: 10.1111/ina.12351.
Singh, M., Hays, A. Indoor and outdoor allergies. (2016). Primary Care, 43,451-463. doi: 10.1016/j.pop.2016.04.013.
Yamamoto, N., Matsuki, Y., Yokoyama, H., Matsuki, H. Relationships among indoor, outdoor, and personal airborne Japanese cedar pollen counts. PLoS One. 2015, 10:e0131710. doi: 10.1371/journal.pone.0131710.
Oeder, S., Jörres, R. A., Weichenmeier, I., Pusch, G., Schober, W., Pfab, F., Behrendt, H., Schierl, R., Kronseder, A., Nowak, D., Dietrich, S., Fernández-Caldas, E., Lintelmann, J., Zimmermann, R., Lang, R., Mages, J., Fromme, H., Buters, J. T. (2012). Airborne indoor particles from schools are more toxic than outdoor particles. American Journal of Respiratory Cell and Molecular Biology, 47,575-582. doi: 10.1165/rcmb.2012-0139OC.
Pongracic, J. A., O'Connor, G. T., Muilenberg, M. L., Vaughn, B., Gold, D. R., Kattan, M., Morgan, W. J., Gruchalla, R. S., Smartt, E., Mitchell, H. E. Differential effects of outdoor versus indoor fungal spores on asthma morbidity in inner-city children. (2010). Journal of Allergy and Clinical Immunology, 125,593-599. doi: 10.1016/j.jaci.2009.10.036.
Jantunen, J., Saarinen, K. (2009). Intrusion of airborne pollen through open windows and doors. Aerobiologia, 25,193-201.
Bielory, L., Deener, A. (1998). Seasonal variation in the effects of major indoor and outdoor environmental variables on asthma. Journal of Asthma, 35,7-48.
Sterling, D. A., Lewis, R. D. (1998). Pollen and fungal spores indoor and outdoor of mobile homes. Annals of Allergy Asthma and Immunology, 80: 279-285.
Beachy, S. H., Repasky, E. A. (2011). Toward establishment of temperature thresholds for immunological impact of heat exposure in humans. International Journal of Hyperthermia, 27,344-352. doi: 10.3109/02656736.2011.562873.
Directive 89/391/EEC of the Council of 12 June 1989 on the introduction of measures to encourage improvements in the safety and health of workers at work. Official Journal of the European Communities L183/1. 29.6.89.
Directive 98/24/EC of the Council of 7 April 1998 on the protection of the health and safety of workers from the risks related to chemical agents at work (fourteenth individual Directive within the meaning of Article 16(1) of Directive 89/391/EEC). Official Journal of the European Communities L 131/11. 5.5.98.
Directive 2004/37/EC of the European Parliament and of the Council of 29 April 2004 on the protection of workers from the risks related to exposure to carcinogens or mutagens at work (Sixth individual Directive within the meaning of Article 16(1) of Council Directive 89/391/EEC. Official Journal of the European Union. L 229/23. 29.6.2004.
Dunin-Bell, O. What do they know? Guidelines and knowledge translation for foreign health sector workers following natural disasters. (2018). Prehospital and Disaster Medicine, 33,139-146. doi: 10.1017/S1049023X18000146.
Murphy, G. T., Birch, S., Mackenzie, A., Rigby, J., Langley J. (2017). An integrated needs-based approach to health service and health workforce planning: applications for pandemic influenza. Healthcare Policy, 13,28-42.
Uejio, C. K., Morano, L. H., Jung, J., Kintziger, K., Jagger, M., Chalmers, J., Holmes, T. (2018). Occupational heat exposure among municipal workers. International Archives of Occupational and Environmental Health, 9,705-715. doi: 10.1007/s00420-018-1318-3.
Piedrahita, H., Oksa, J., Malm, C., Rintamäki, H. (2008). Health problems related to working in extreme cold conditions indoors. International Journal of Circumpolar Health, 67,279-287.
D'Amato, G., Annesi-Maesano, I., Cecchi, L., D'Amato, M. (2018). Latest news on relationship between thunderstorms and respiratory allergy, severe asthma, and deaths for asthma. Allergy, Sep 22. doi: 10.1111/all.13616.
Thien, F., Beggs, P. J., Csutoros, D., Darvall, J., Hew, M., Davies, J. M., Bardin, P. G., Bannister, T., Barnes, S, Bellomo, R., Byrne, T., Casamento, A., Conron, M., Cross, A., Crosswell, A., Douglass, J. A., Durie, M., Dyett, J., Ebert, E., Erbas, B., French, C., Gelbart, B., Gillman, A., Harun, N. S., Huete, A., Irving, L., Karalapillai, D., Ku, D., Lachapelle, P., Langton, D., Lee, J., Looker, C., MacIsaac, C., McCaffrey, J., McDonald, C. F., McGain, F., Newbigin, E., O'Hehir, R., Pilcher, D., Prasad, S., Rangamuwa, K., Ruane, L., Sarode V., Silver J. D., Southcott A. M., Subramaniam, A., Suphioglu, C., Susanto, N. H., Sutherland, M. F., Taori, G., Taylor, P., Torre, P., Vetro, J., Wigmore, G., Young, A. C., Guest, C. The Melbourne epidemic thunderstorm asthma event 2016: an investigation of environmental triggers, effect on health services, and patient risk factors. (2018). Lancet Planet Health, 2, e255-e263. doi: 10.1016/S2542-5196(18)30120-7.
Clayton-Chubb, D., Con, D., Rangamuwa, K., Taylor, D., Thien, F., Wadhwa, V. Thunderstorm asthma - revealing a hidden at-risk population. (2018). Internal Medicine Journal, Mar 23. doi: 10.1111/imj.13800.
Grandi, C., D’Ovidio, M. C. Climate change and occupational health and safety: characterization and protection of outdoor workers belonging to particularly sensitive risk groups. XXXIV Giornata dell’Ambiente. Strategie di adattamento al cambiamento climatico (Roma, 8 novembre 2016). Atti dei Convegni Lincei 320. Roma 2018. Pagine: 199-205. Bardi Edizioni - Editore Commerciale - ISSN: 0391-805X - ISBN: 978-88-218-1167-8.
Wild, C. P. (2005). Complementing the genome with an “exposome”: the outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiology, Biomarkers & Prevention, 14,1847-1850.
Miller, G. W. The Exposome: A Primer. Academic Press, Elsevier, Inc. Waltham, MA, 2014.
Andrianou, X. D., Makris, K. C. (2018). The framework of urban exposome: Application of the exposome concept in urban health studies. Science of Total Environment, 636,963-967. doi: 10.1016/j.scitotenv.2018.04.329.
Dai, D., Prussin A. J. 2nd., Marr, L. C., Vikesland, P. J., Edwards, M. A., Pruden, A. (2017). Factors shaping the human exposome in the built environment: opportunities for engineering control. Environmental Science and Technology, 51,7759-7774. doi: 10.1021/acs.est.7b01097.
Maitre, L., de Bont, J., Casas, M., Robinson, O., Aasvang, G. M., Agier, L., Andrušaitytė, S., Ballester, F., Basagaña, X., Borràs, E., Brochot, C., Bustamante, M., Carracedo, A., de Castro, M., Dedele, A., Donaire-Gonzalez, D., Estivill, X., Evandt, J., Fossati, S., Giorgis-Allemand, L., R Gonzalez, J., Granum, B., Grazuleviciene, R., Bjerve Gützkow, K., Småstuen Haug, L., Hernandez-Ferrer C., Heude B., Ibarluzea J., Julvez. J., Karachaliou, M., Keun, H. C., Hjertager Krog, N., Lau, C. E., Leventakou, V., Lyon-Caen, S., Manzano, C., Mason, D., McEachan, R., Meltzer, H. M., Petraviciene, I., Quentin, J., Roumeliotaki, T., Sabido, E., Saulnier, P. J., Siskos, A. P., Siroux, V., Sunyer, J., Tamayo, I., Urquiza, J., Vafeiadi, M., van Gent, D., Vives-Usano, M., Waiblinger, D., Warembourg, C., Chatzi, L., Coen, M., van den Hazel, P., Nieuwenhuijsen, M. J., Slama, R., Thomsen, C., Wright, J., Vrijheid, M. (2018). Human Early Life Exposome (HELIX) study: a European population-based exposome cohort. British Medical Journal Open, 8,9:e021311. doi: 10.1136/bmjopen-2017-021311.
Rappaport, S. M. Redefining environmental exposure for disease etiology. (2018). NPJ Systems Biology and Applications, 4,30. doi: 10.1038/s41540-018-0065-0.
Niedzwiecki, M. M., Walker, D. I., Vermeulen, R., Chadeau-Hyam, M., Jones, D. P., Miller, G. W. (2018). The exposome: molecules to populations. Annual Review of Pharmacology and Toxicology, Aug 10. doi: 10.1146/annurev-pharmtox-010818-021315.
Coughlin, S. S. (2014). Toward a road map for global -omics: a primer on -omic technologies. American Journal of Epidemiology, 180, 1188-1195. doi: 10.1093/aje/kwu262.
Martyniuk, C. J., Simmons, D. B. (2016). Spotlight on environmental omics and toxicology: a long way in a short time. Comparative Biochemistry and Physiology, Part D Genomics Proteomics, 19, 97-101. doi: 10.1016/j.cbd.2016.06.010.
Liu, Y., Hoppe, B. O., Convertino, M. (2018). Threshold evaluation of emergency risk communication for health risks related to hazardous ambient temperature. Risk Analysis, 38,2208-2221. doi: 10.1111/risa.12998.
Ristevski, B., Chen, M. Big data analytics in medicine and healthcare. (2018). Journal of Integrative Bioinformatics, 15, doi: 10.1515/jib-2017-0030.
Lee, E. C., Arab, A., Goldlust, S. M., Viboud, C., Grenfell, B. T, Bansal, S. (2018). Deploying digital health data to optimize influenza surveillance at national and local scales. PLoS Computational Biology, 14, e1006020. doi: 10.1371/journal.pcbi.1006020.
Xie, J., M. a,. A, Fennell, A., Ma, Q., Zhao, J. (2018). It is time to apply biclustering: a comprehensive review of biclustering applications in biological and biomedical data. Briefings in Bioinformatics. Feb 27. doi: 10.1093/bib/bby014.
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